望月 慎一／モチヅキ シンイチ／Shinichi Mochizuki
| 所属 | 【学部】環境生命工学科 【大学院】環境システム専攻バイオシステムコース |
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| 役職/職名 | 専任教員 | |
| 学位（授与機関） | 工学博士（九州大学） | |
| 略歴 |
2008年 九州大学大学院 物質創造工学専攻 博士後期課程修了（学位取得） |
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| 専門分野 | 生体高分子科学、薬物送達システム | |
業績紹介
1. Matsuda M, Mochizuki S. Control of A/D type CpG-ODN aggregates to a suitable size for induction of strong immunostimulant activity. Biochem. Biophys. Res., 36, 101573 (2023).
2. Ogata S, Tsuji R, Moritaka A, Ito S, Mochizuki S. Modification of antigenicity of cancer cells by conjugate consisting of hyaluronic acid and foreign antigen. Biomater. Sci., 11(17), 5809-5818 (2023).
3. Irie H, Morita K, Matsuda M, Koizumi M, Mochizuki S. Tyrosinase-related protein2 peptide with replacement of N-terminus residue by cysteine binds to H-2Kb and induces antigen-specific cytotoxic T lymphocytes after conjugation with CpG-DNA. Bioconj. Chem., 34(2), 433-442 (2023).
4. Tsuji R, Ogata S, Mochizuki S. Interaction between CD44 and highly condensed hyaluronic acid through crosslinking with proteins. Bioorg. Chem., 121, 105666 (2022).
5. Mochizuki S, Miyamoto N, Sakurai K. Oligonucleotide delivery to antigen presenting cells by using schizophyllan. Drug. Metab. Pharmacokinet., 42, 100434 (2022).
6. Fujiwara N, Izumi H, Kira R, Morimoto Y, Mochizuki S, Sakurai K. Binding assay of human Dectin-1 variants to DNA/β-glucan complex for active-targeting delivery of antisense DNA. Carbohydr. Res., 500, 108219 (2021).
7. Takahara M, Mochizuki S, Wakabayashi R, Minamihara K, Goto M, Sakurai K, Kamiya N. Extending the Half-Life of a Protein in Vivo by Enzymatic Labeling with Amphiphilic Lipopeptides. Bioconj. Chem., 32(4), 655-660 (2021).
8. Irie H, Morita K, Koizumi M, Mochizuki S. Immune Responses and Antitumor Effect through Delivering to Antigen Presenting Cells by Optimized Conjugates Consisting of CpG-DNA and Antigenic Peptide. Bioconj. Chem., 31(11), 2585-2595 (2020).
9. Sasaki S, Izumi H, Morimoto M, Sakurai K, Mochizuki S. Induction of potent cell growth inhibition by Schizophyllan/K-ras antisense complex in combination with gemcitabine. Bioorg. Med. Chem., 28(18), 115668 (2020).
10. Fujiwara N, Izumi H, Morimoto Y, Sakurai K, Mochizuki S. Complex Consisting of Antisense DNA and b-glucan Promotes Internalization into Cell through Dectin-1 and Hybridizes with Target mRNA in Cytosol. Cancer Gene Ther., 26, 32-40 (2019).
11. Mochizuki S, Morishita H, Sakurai K. Complex consisting of β-Glucan and antigenic peptides with cleavage site for glutathione and aminopeptidases induces potent cytotoxic T lymphocytes. Bioconj. Chem., 28(9), 2246-2253 (2017).
12. Miyamoto N, Mochizuki S, Fujii S, Yoshida K, Sakurai K. Adjuvant activity enhanced by cross-linked CpG-oligonucleotides in β-glucan nanogel and its antitumor effect. Bioconj. Chem., 28(2), 565-573 (2017).
13. Miyamoto N, Fujii S, Mochizuki S, Sakurai K. A two-component micelle with emergent pH responsiveness by mixing dilauroyl phosphocholine and deoxycholic acid and its delivery of proteins into the cytosol. Colloids Surf. B Biointerfaces, 154, 246-252 (2017).
14. Maegawa Y, Mochizuki S, Miyamoto N, Sakurai K. Gene silencing using a conjugate comprising Tat peptide and antisense oligonucleotide with phosphorothioate backbones. Bioorg. Med. Chem. Lett., 26(4), 1276-1278 (2016).
15. Izumi H, Nagao S, Mochizuki S, Fujiwara N, Sakurai K. Optimal sequence of antisense DNA to silence YB-1 in lung cancer by use of a novel polysaccharide drug delivery system. Int. J. Oncol., 48(6), 2472-2478 (2016).
16. Fukuda I, Mochizuki S, Sakurai K. Competition of PEG coverage density and con-A recognition in mannose/PEG bearing nanoparticles. Colloids Surf. B Biointerfaces. 146, 642-648 (2016).
17. Shiraishi K, Kawano K, Maitani Y, Aoshi T, Ishii KJ, Sanada Y, Mochizuki S, Sakurai K, Yokoyama M. Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance. J. Control. Release, 234, 59-67 (2016).
18. Mochizuki S, Morishita H, Kobiyama K, Aoshi T, Ishii KJ, Sakurai K. Immunization with antigenic peptides complexed with β-glucan induces potent cytotoxic T-lymphocyte activity in combination with CpG-ODNs. J. Control. Release, 220, 495-502 (2015).
19. Mochizuki S, Nishina K, Fujii S, Sakurai K. The transfection efficiency of calix[4]arene-based lipids: the role of the alkyl chain length. Biomater. Sci., 3(2), 317-322 (2015).
20. Maegawa Y, Mochizuki S, Miyamoto N, Sanada Y, Sakurai K. Application toward drug delivery system using b-1,3-glucan. Trends Glycosci. Glycotechnol., 27(153), 13-29 (2015).
21. Sakashita M, Mochizuki S, Kazuo S. Hepatocyte-targeting gene delivery using a lipoplex composed of galactose-modified aromatic lipid synthesized with click chemistry. Bioorg. Med. Chem., 22(19), 5212-5219 (2014).
22. Mochizuki S, Morishita H, Adachi Y, Yamaguchi Y, Sakurai K. Binding assay between murine Dectin-1 and b-glucan/DNA complex with quartz-crystal microbalance. Carbohydr. Res., 391, 1-8 (2014).
23. Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc. Natl. Acad. Sci. U.S.A. 111(8), 3086-3091 (2014).
24. Maeda K, Mochizuki S, Sakurai K. Naphthalene-hydrophobized b-1,3-glucan nanogel for doxorubicin delivery to immunocytes. Bioorg. Med. Chem. Lett., 24(8), 1880-1883 (2014).
25. Maegawa Y, Mochizuki S, Sanada Y, Akiyoshi K, Sakurai K. Dual-sugar nanogel comprising b-1,3-glucan and cholesterol-bearing dextran for protein-delivery targeting antigen presenting cells. Chem. Lett., 43(5), 652-654 (2014).
26. Yamasaki T, Ariyoshi W, Okinaga T, Adachi Y, Hosokawa R, Mochizuki S, Sakurai K, Nishihara T. Dectin-1 agonist, curdlan, regulates osteoclastogenesis by inhibiting nuclear factor of activated T-cells cytoplasmic 1 through Syk kinase. J. Biol. Chem., 289(27), 19191-19203 (2014).
27. Miyamoto N, Mochizuki S. Sakurai K. Enhanced immunostimulation with crosslinked CpG-DNA/ b- 1,3-glucan nanoparticle through hybridization. Chem. Lett., 43(7), 991-993 (2014).
28. Mochizuki S, Morishita H, Sakurai K. Macrophage specific delivery of TNF-a siRNA complexed with b-1,3-glucan inhibits LPS-induced cytokine production in a murine acute hepatitis model. Bioorg. Med. Chem., 21(9), 2535-2542 (2013).
29. Li W.J, Mochizuki S, Sakurai K. Structural transitioin of lipopolysaccharide and reduction in the biological activity by amphiphilic lipid with cationic amino acid. Bull. Chem. Soc. Jpn., 86(5), 651-656 (2013).
30. Mochizuki S, Higuchi S, Sakurai K. ssDNA–dsRNAs are cleaved at the next to its chimera-junction point by an unknown RNase activity. Biochem. Biophys. Res. Commun., 428(4), 433-437 (2012).
31. Mochizuki S, Kanegae N, Nishina K, Kamikawa Y, Koiwai K, Masunaga H, Sakurai K. The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine. Biochim. Biophys. Acta.1828(2), 412-418 (2012).
32. Mochizuki S, Kamikawa Y, Nizhina K, Fujii S, Hamada E, Kusuki S, Matsuo T, Sakurai K. Relationship between DNA-transfection efficiency and chemical structures of aromatic cationic lipids. Bull. Chem. Soc. Jpn., 85(3), 354-359 (2012).
33. Sanada Y, Matsuzaki T, Mochizuki S, Okobira T, Uezu K, Sakurai K. b-1,3-glucan schizophyllan/poly(dA) triple-helical complex in dilute solution. J. Phys. Chem. B, 116(1), 87-94 (2012).
34. Mochizuki S, Sakurai K. Dectin-1 targeting delivery of TNF-a antisense ODNs complexed with b-1,3-glucan protects mice from LPS-induced hepatitis. J. Control. Release, 151(2), 155-61 (2011).
35. Minari J, Mochizuki S, Matsuzaki T, Adachi Y, Ohno N, Sakurai K. Enhanced cytokine secretion from primary macrophages due to dectin-1 mediated uptake of CpG DNA/β-1,3-glucan complex. Bioconj. Chem., 22(1), 9-15 (2011).
36. Mochizuki S, Sakurai K. b-1,3-glucan/antisense oligonucleotide complex stabilized with phosphorothioation and its gene suppression. Bioorg. Chem., 38(6), 260-264 (2010).
37. Mochizuki S, Sakurai K. A novel polysaccharide/polynucleotide complex and its application to bio-functional DNA delivery system. Polymer Journal, 41(5), 343-353 (2009).
38. Mochizuki S, Kano A, Shimada N, Maruyama A. Uptake of enzymatically-digested hyaluronan by liver endothelial cells in vivo and in vitro. J. Biomater. Sci. Polym. Ed., 20(1), 83-97 (2009).
39. Minari J, Mochizuki S, Sakurai K. Enhanced cytokine secretion owing to multiple CpG side chains of DNA duplex. Oligonucleotides, 18(4), 337-344 (2008).
40. Mochizuki S, Kano A, Yamayoshi A, Maruyama A. Hyaluronan conjugation of antigenic protein to modify immunogenic information. Sci. Technol. Adv. Mater., 7(7), 685-691 (2006).
企業メッセージ
生体材料を用いた薬物送達システムの開発をしています。様々な医学部の先生方との共同研究を通して臨床応用を目指しています。詳しくはHPにアクセスして下さい。